Consideration of the Possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues.


A model is proposed to account for the observation that the denaturation of small proteins apparently occurs in two kinetic phases. It is suggested that only one of these phases--the fast one--is actually an unfolding process. The slow phase is assumed to arise from the cis-trans isomerism of proline residues in the denaturated protein. From model compound… (More)


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