Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells.

@article{Garg2019ConsiderTL,
  title={Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells.},
  author={Ankur Garg and Pengfei Sui and Jamie M. Verheyden and Lisa R. Young and Xin Sun},
  journal={Current topics in developmental biology},
  year={2019},
  volume={132},
  pages={
          67-89
        }
}
  • A. GargP. Sui Xin Sun
  • Published 2019
  • Biology, Medicine
  • Current topics in developmental biology

Pulmonary neuroendocrine cells: physiology, tissue homeostasis and disease

The physiological relevance of pulmonary neuroendocrine cells, rare airway epithelial cells that form intrapulmonary sensory organs, abnormalities of which are associated with several pulmonary disorders, such as asthma and lung cancer, are highlighted.

Influence of pulmonary neuroendocrine cells on lung homeostasis

The aim of this work is to analyze the modern scientific literature data on the effect of PNECs on the lung homeostasis in normal and pathological conditions and to suggest a neuroimmunological module for the reception and response to environmental chemoattractants.

Lung epithelium development and airway regeneration

Understanding the basic mechanisms of lung development and the behavior of progenitor cell in the ontogeny and regeneration of the lung may help to better understand the underlying cause of lung diseases, especially those occurring in prenatal development or in the immediate postnatal period of life.

Epithelial barriers in allergy and asthma

Eosinophil extracellular traps drive asthma progression through neuro-immune signals.

It is shown that eosinophil extracellular traps in bronchoalveolar lavage fluid are associated with the severity of asthma in patients, and a previously unknown role of EETs in integrating immunological and neurological cues to drive asthma progression is demonstrated.

Cellular and functional heterogeneity of the airway epithelium

Recent advances regarding the cellular and functional heterogeneity along the airway epithelium are highlighted and how this knowledge can be used to design more effective, targeted therapeutics is discussed.

Mechanisms and biomarkers of airway epithelial cell damage in asthma: A review

The evidence for ongoing epithelial cell dysregulation in the pathogenesis of asthma, the sentinel role of the airway epithelium, and how understanding these molecular mechanisms provides the basis for the identification of candidate biomarkers for asthma prediction, prevention, diagnosis, treatment and monitoring are reviewed.

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