Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells.

@article{Garg2019ConsiderTL,
  title={Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells.},
  author={Ankur Garg and Pengfei Sui and Jamie M. Verheyden and Lisa R. Young and Xin Sun},
  journal={Current topics in developmental biology},
  year={2019},
  volume={132},
  pages={
          67-89
        }
}
  • A. Garg, P. Sui, Xin Sun
  • Published 2019
  • Biology, Medicine
  • Current topics in developmental biology
Pulmonary neuroendocrine cells: physiology, tissue homeostasis and disease
TLDR
The physiological relevance of pulmonary neuroendocrine cells, rare airway epithelial cells that form intrapulmonary sensory organs, abnormalities of which are associated with several pulmonary disorders, such as asthma and lung cancer, are highlighted.
Influence of pulmonary neuroendocrine cells on lung homeostasis
TLDR
The aim of this work is to analyze the modern scientific literature data on the effect of PNECs on the lung homeostasis in normal and pathological conditions and to suggest a neuroimmunological module for the reception and response to environmental chemoattractants.
Epithelial barriers in allergy and asthma
Eosinophil extracellular traps drive asthma progression through neuro-immune signals.
TLDR
It is shown that eosinophil extracellular traps in bronchoalveolar lavage fluid are associated with the severity of asthma in patients, and a previously unknown role of EETs in integrating immunological and neurological cues to drive asthma progression is demonstrated.
Cellular and functional heterogeneity of the airway epithelium
TLDR
Recent advances regarding the cellular and functional heterogeneity along the airway epithelium are highlighted and how this knowledge can be used to design more effective, targeted therapeutics is discussed.
Mechanisms and biomarkers of airway epithelial cell damage in asthma: A review
TLDR
The evidence for ongoing epithelial cell dysregulation in the pathogenesis of asthma, the sentinel role of the airway epithelium, and how understanding these molecular mechanisms provides the basis for the identification of candidate biomarkers for asthma prediction, prevention, diagnosis, treatment and monitoring are reviewed.
Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells
...
1
2
3
4
...

References

SHOWING 1-10 OF 122 REFERENCES
Pulmonary neuroendocrine cells function as airway sensors to control lung immune response
TLDR
It is demonstrated in vivo that PNECs act as precise airway sensors that elicit immune responses via neuropeptides, suggesting that the PNec and Neuropeptide abnormalities documented in a wide array of pulmonary diseases may profoundly affect symptoms and progression.
Pulmonary neuroendocrine cells amplify allergic asthma responses
TLDR
In vitro data show that pulmonary neuroendocrine cells (PNECs), a rare airway epithelial cell population, can act as chemosensors, and the underlying mechanisms by identifying molecular effectors and cellular targets of PNECs are elucidated.
Pulmonary Neuroendocrine Cell System in Pediatric Lung Disease—Recent Advances
  • E. Cutz, H. Yeger, Jie Pan
  • Medicine, Biology
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2007
TLDR
Recent findings pertaining to the responses of PNEC to intrauterine environmental stimuli, ontogeny and molecular regulation of PnEC differentiation, innervation of NEB, and their role as airway chemoreceptors are discussed, including mechanisms of O2 sensing and chemotransmission of hypoxia stimulus.
Chemosensory functions for pulmonary neuroendocrine cells.
TLDR
It is shown that solitary pulmonary neuroendocrine cells (PNECs), which are morphologically distinct and physiologically undefined, might serve as chemosensory cells in human airways, and that the distribution of serotonin and neuropeptide receptors may change in chronic obstructive pulmonary disease, suggesting that increased PNEC-dependent chemoresponsiveness might contribute to the altered sensitivity to volatile stimuli in this disease.
Functional facets of the pulmonary neuroendocrine system
  • R. Linnoila
  • Biology, Medicine
    Laboratory Investigation
  • 2006
TLDR
For the first time ever, mouse models for lung NE carcinomas, including the most common and virulent small cell lung carcinoma, are presented, indicating an exciting new era for PNECs and are likely to have therapeutic and diagnostic applications.
Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis
TLDR
A genetic tool developed in mice by introducing a fusion protein of Cre recombinase and estrogen receptor into the calcitonin gene-related peptide (CGRP) locus that encodes a major peptide in PNECs revealed the plasticity of PnECs and suggested that SCLC can originate from differentiated PN ECs.
Neuroepithelial bodies: A morphologic substrate for the link between neuronal nitric oxide and sensitivity to airway hypoxia?
TLDR
Part of the pulmonary NEBs selectively receive extensive nitrergic nerve terminals that originate from intrinsic neurons, as well as the CGRP‐IR afferents described in the present study.
Oxygen sensing in airway chemoreceptors
TLDR
The identification of an oxygen-sensing mechanism (namely the presence of an O1-sensitive potassium channel coupled to an O2 sensor protein5) in the cells of pulmonary neuroepithelial bodies indicates that they are transducers of the hypoxia stimulus and hence may function as airway chemoreceptors in the regulation of respiration.
...
1
2
3
4
5
...