Conserved water molecules in the specificity pocket of serine proteases and the molecular mechanism of Na+ binding.

@article{Krem1998ConservedWM,
  title={Conserved water molecules in the specificity pocket of serine proteases and the molecular mechanism of Na+ binding.},
  author={Maxwell M. Krem and Enrico Di Cera},
  journal={Proteins},
  year={1998},
  volume={30 1},
  pages={34-42}
}
Conservation of clusters of buried water molecules is a structural motif present throughout the serine protease family. Frequently, these clusters are shaped as water channels forming extensive hydrogen-bonding networks linked to the protein backbone. The most conspicuous example is the water channel present in the specificity pocket of trypsin and thrombin… CONTINUE READING