Conserved structure and expression of hsp70 paralogs in teleost fishes.

@article{Metzger2016ConservedSA,
  title={Conserved structure and expression of hsp70 paralogs in teleost fishes.},
  author={David C H Metzger and Jakob Hemmer-Hansen and Patricia M Schulte},
  journal={Comparative biochemistry and physiology. Part D, Genomics & proteomics},
  year={2016},
  volume={18},
  pages={10-20}
}
The cytosolic 70KDa heat shock proteins (Hsp70s) are widely used as biomarkers of environmental stress in ecological and toxicological studies in fish. Here we analyze teleost genome sequences to show that two genes encoding inducible hsp70s (hsp70-1 and hsp70-2) are likely present in all teleost fish. Phylogenetic and synteny analyses indicate that hsp70-1 and hsp70-2 are distinct paralogs that originated prior to the diversification of the teleosts. The promoters of both genes contain a TATA… CONTINUE READING