Conserved stem-loop structures in the HIV-1 RNA region containing the A3 3' splice site and its cis-regulatory element: possible involvement in RNA splicing.

@article{Jacquenet2001ConservedSS,
  title={Conserved stem-loop structures in the HIV-1 RNA region containing the A3 3' splice site and its cis-regulatory element: possible involvement in RNA splicing.},
  author={Sandrine Jacquenet and Delphine Ropers and Patricia S. Bilodeau and Laurence Damier and Annie Mougin and C. Martin Stoltzfus and Christiane Branlant},
  journal={Nucleic acids research},
  year={2001},
  volume={29 2},
  pages={464-78}
}
The HIV-1 transcript is alternatively spliced to over 30 different mRNAs. Whether RNA secondary structure can influence HIV-1 RNA alternative splicing has not previously been examined. Here we have determined the secondary structure of the HIV-1/BRU RNA segment, containing the alternative A3, A4a, A4b, A4c and A5 3' splice sites. Site A3, required for tat mRNA production, is contained in the terminal loop of a stem-loop structure (SLS2), which is highly conserved in HIV-1 and related SIVcpz… CONTINUE READING