Conserved sequence box II directs transcription termination and primer formation in mitochondria.

@article{Pham2006ConservedSB,
  title={Conserved sequence box II directs transcription termination and primer formation in mitochondria.},
  author={Xuan Hoi Pham and G{\'e}raldine Farge and Yonghong Shi and Martina Gaspari and Claes M. Gustafsson and Maria Falkenberg},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 34},
  pages={24647-52}
}
The human mitochondrial transcription machinery generates the RNA primers needed for initiation of heavy strand DNA synthesis. Most DNA replication events from the heavy strand origin are prematurely terminated, forming a persistent RNA-DNA hybrid, which remains annealed to the parental DNA strand. This triple-stranded structure is called the D-loop and encompasses the conserved sequence box II, a DNA element required for proper primer formation. We here use a purified recombinant mitochondrial… CONTINUE READING
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