Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development.

@article{Morrison2006ConservedRF,
  title={Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development.},
  author={Gillian M. Morrison and Joshua M Brickman},
  journal={Development},
  year={2006},
  volume={133 10},
  pages={
          2011-22
        }
}
All vertebrate embryos have multipotent cells until gastrulation but, to date, derivation of embryonic stem (ES) cell lines has been achieved only for mouse and primates. ES cells are derived from mammalian inner cell mass (ICM) tissue that express the Class V POU domain (PouV) protein Oct4. Loss of Oct4 in mice results in a failure to maintain ICM and consequently an inability to derive ES cells. Here, we show that Oct4 homologues also function in early amphibian development where they act as… CONTINUE READING

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