Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.

@article{Son2015ConservedRO,
  title={Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.},
  author={Eun Jin Son and Ji-Hyun Ma and Harinarayana Ankamreddy and Jeong-Oh Shin and Jae Young Choi and Doris K Wu and Jinwoong Bok},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 12},
  pages={3746-51}
}
Sound frequency discrimination begins at the organ of Corti in mammals and the basilar papilla in birds. Both of these hearing organs are tonotopically organized such that sensory hair cells at the basal (proximal) end respond to high frequency sound, whereas their counterparts at the apex (distal) respond to low frequencies. Sonic hedgehog (Shh) secreted… CONTINUE READING