Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

@article{Walker2010ConservedRO,
  title={Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.},
  author={Amy K Walker and Fajun Yang and Karen Jiang and Jun-Yuan Ji and Jennifer L Watts and Aparna Purushotham and Olivier Boss and Michael Hirsch and Scott A Ribich and Jesse J. Smith and Kristine Israelian and Christoph Westphal and Joseph Thomas Rodgers and Toshi Shioda and S Alvarenga Elson and P. See Mulligan and Hani Najafi-Shoushtari and Josh C. Black and Jitendra Kumar Thakur and Lisa C. Kadyk and Johnathan R. Whetstine and Ra{\'u}l Mostoslavsky and Pere B. Puigserver and Xiaoling Li and Nicholas John Dyson and Anne C Hart and Anders M. N{\"a}{\"a}r},
  journal={Genes & development},
  year={2010},
  volume={24 13},
  pages={
          1403-17
        }
}
The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and facilitate fat storage. During fasting, SREBP-dependent lipid/cholesterol synthesis is rapidly diminished in the mouse liver; however, the mechanism has remained incompletely understood. Moreover, the evolutionary… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 138 CITATIONS, ESTIMATED 54% COVERAGE

Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation.

  • Cell reports
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Regulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1).

  • The Journal of biological chemistry
  • 2014
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

SIRT1 metabolic actions: Integrating recent advances from mouse models★

  • Molecular metabolism
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Seven sirtuins for seven deadly diseases of aging.

  • Free radical biology & medicine
  • 2013
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?

  • Pharmacological reviews
  • 2012
VIEW 6 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 11 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 76 REFERENCES

The role of sirtuins in the control of metabolic homeostasis.

  • Annals of the New York Academy of Sciences
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.

  • The Journal of biological chemistry
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL