Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes

@article{Kalueff2010ConservedRF,
  title={Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes},
  author={Allan V Kalueff and Jocelien D A Olivier and Lourens J. P. Nonkes and Judith R Homberg},
  journal={Neuroscience & Biobehavioral Reviews},
  year={2010},
  volume={34},
  pages={373-386}
}
The serotonin transporter knockout (SERT(-/-)) mouse, generated in 1998, was followed by the SERT(-/-) rat, developed in 2006. The availability of SERT(-/-) rodents creates the unique possibility to study the conservation of gene function across species. Here we summarize SERT(-/-) mouse and rat data, and discuss species (dis)similarities in neurobehavioral endophenotypes. Both SERT(-/-) rodent models show a disturbed serotonergic system, altered nociception, higher anxiety, decreased social… CONTINUE READING
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