Conserved residues and the mechanism of protein folding

@article{Shakhnovich1996ConservedRA,
  title={Conserved residues and the mechanism of protein folding},
  author={Eugene Shakhnovich and V. I. Abkevich and O. B. Ptitsyn},
  journal={Nature},
  year={1996},
  volume={379},
  pages={96-98}
}
EXPERIMENTAL1–6 and simulation7 studies show that small mono-meric proteins fold in one kinetic step, which entails overcoming the free-energy barrier between the unfolded and the native protein through a transition state8,9. Two models of transition state formation have been proposed: a 'nonspecific' one in which it depends on the formation of a sufficient number of native-like contacts regardless of what amino acids are involved10–12, and a 'specific' one, in which it depends on formation of… CONTINUE READING

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