Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.

@article{Shiratori2006ConservedRA,
  title={Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.},
  author={Hidetaka Shiratori and Kenta Yashiro and Michael M Shen and Hiroshi Hamada},
  journal={Development},
  year={2006},
  volume={133 15},
  pages={
          3015-25
        }
}
Pitx2 is expressed in developing visceral organs on the left side and is implicated in left-right (LR) asymmetric organogenesis. The asymmetric expression of Pitx2 is controlled by an intronic enhancer (ASE) that contains multiple Foxh1-binding sites and an Nkx2-binding site. These binding sites are essential and sufficient for asymmetric enhancer activity and are evolutionarily conserved among vertebrates. We now show that mice that lack the ASE of Pitx2 (Pitx2(Delta)(ASE/)(Delta)(ASE) mice… CONTINUE READING

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