Conserved region 2.1 of Escherichia coli heat shock transcription factor sigma32 is required for modulating both metabolic stability and transcriptional activity.

@article{Horikoshi2004ConservedR2,
  title={Conserved region 2.1 of Escherichia coli heat shock transcription factor sigma32 is required for modulating both metabolic stability and transcriptional activity.},
  author={Mina Horikoshi and Takashi Yura and Sachie Tsuchimoto and Yoshihiro Fukumori and Masaaki Kanemori},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 22},
  pages={7474-80}
}
Escherichia coli heat shock transcription factor sigma32 is rapidly degraded in vivo, with a half-life of about 1 min. A set of proteins that includes the DnaK chaperone team (DnaK, DnaJ, GrpE) and ATP-dependent proteases (FtsH, HslUV, etc.) are involved in degradation of sigma32. To gain further insight into the regulation of sigma32 stability, we isolated sigma32 mutants that were markedly stabilized. Many of the mutants had amino acid substitutions in the N-terminal half (residues 47 to 55… CONTINUE READING

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