Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

@article{Langosch1988ConservedQS,
  title={Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.},
  author={Dieter Langosch and Linda T. Thomas and Heinrich Betz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 19},
  pages={7394-8}
}
The postsynaptic glycine receptor of rat spinal cord is a glycosylated membrane protein that, after affinity purification, contains membrane-spanning subunits of Mr 48,000 and 58,000 and an associated peripheral polypeptide of Mr 93,000. Here, the quaternary structure of the transmembrane core of the receptor was investigated by chemically crosslinking its… CONTINUE READING