Conserved proteins are fragile.

@article{Assis2014ConservedPA,
  title={Conserved proteins are fragile.},
  author={Raquel Assis and Alexey S. Kondrashov},
  journal={Molecular biology and evolution},
  year={2014},
  volume={31 2},
  pages={419-24}
}
Levels of selective constraint vary among proteins. Although strong constraint on a protein is often attributed to its functional importance, evolutionary rate may also be limited if a protein is fragile, such that a large proportion of amino acid replacements reduce its fitness. To determine the relative contributions of essentiality and fragility to selective constraint, we compared relationships of selection against nonsense mutations (snon) and selection against missense mutations (smis) to… CONTINUE READING
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