Conserved principles of mammalian transcriptional regulation revealed by RNA half-life

@inproceedings{Friedel2009ConservedPO,
  title={Conserved principles of mammalian transcriptional regulation revealed by RNA half-life},
  author={Caroline C. Friedel and Lars D{\"o}lken and Zsolt Ruzsics and Ulrich Koszinowski and Ralf Zimmer},
  booktitle={Nucleic acids research},
  year={2009}
}
RNA levels in a cell are regulated by the relative rates of RNA synthesis and decay. We recently developed a new approach for measuring both RNA synthesis and decay in a single experimental setting by biosynthetic labeling of newly transcribed RNA. Here, we show that this provides measurements of RNA half-lives from microarray data with a so far unreached accuracy. Based on such measurements of RNA half-lives for human B-cells and mouse fibroblasts, we identified conserved regulatory principles… CONTINUE READING
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Ensembl 2009

  • M. Ashburner, C. A. Ball, +7 authors J. T. Eppig
  • Nucleic Acids Res .
  • 2009

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