Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.

@article{Donnelly1999ConservedPR,
  title={Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.},
  author={Doris Donnelly and Stuart Maudsley and Janeanne Gent and Righetto Moser and Craig R. Hurrell and John B. C. Findlay},
  journal={The Biochemical journal},
  year={1999},
  volume={339 ( Pt 1)},
  pages={
          55-61
        }
}
We have studied the effects of agonist and antagonist binding, agonist-induced activation and agonist-induced desensitization of the human tachykinin NK2 receptor mutated at polar residues Asn-51 [in transmembrane helix 1 (TM1)], Asp-79 (TM2) and Asn-303 (TM7), which are highly conserved in the transmembrane domain in the rhodopsin family of G-protein-coupled receptors. Wild-type and mutant receptors were expressed in both COS-1 cells and Xenopus oocytes. The results show that the N51D mutation… CONTINUE READING

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GTPases in Biology (Dickey, B

  • J.B.C. Findlay, D. Donnelly
  • 1993

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