We implement a strategy for aligning two protein-protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and complexes. Using this approach we show that the protein-protein interaction networks of two distantly related species, Saccharomyces cerevisiae and Helicobacter pylori… (More)
Fig. 3. Paralogous pathways within yeast. To find pathways conserved within yeast, the protein interaction network from S. cerevisiae (green pathways) was compared against a copy of itself (blue pathways). High-scoring pathway alignments are displayed as described for Fig. 2, with cellular functions indicated.