Conserved pathways within bacteria and yeast as revealed by global protein network alignment.

@article{Kelley2003ConservedPW,
  title={Conserved pathways within bacteria and yeast as revealed by global protein network alignment.},
  author={Brian P. Kelley and Roded Sharan and Richard M. Karp and Taylor Sittler and David E Root and Brent R. Stockwell and Trey Ideker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 20},
  pages={
          11394-9
        }
}
We implement a strategy for aligning two protein-protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and complexes. Using this approach we show that the protein-protein interaction networks of two distantly related species, Saccharomyces cerevisiae and Helicobacter pylori, harbor a large complement of evolutionarily conserved pathways, and that a large number of pathways appears to have duplicated and… CONTINUE READING

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