Conserved or Lost: Molecular Evolution of the Key Gene GULO in Vertebrate Vitamin C Biosynthesis

@article{Yang2013ConservedOL,
  title={Conserved or Lost: Molecular Evolution of the Key Gene GULO in Vertebrate Vitamin C Biosynthesis},
  author={Hongwen Yang},
  journal={Biochemical Genetics},
  year={2013},
  volume={51},
  pages={413-425}
}
  • Hongwen Yang
  • Published 12 February 2013
  • Biology
  • Biochemical Genetics
Abstractl-gulono-gamma-lactone oxidase (GULO) catalyzes the final step in vertebrate vitamin C biosynthesis. Vitamin C-incapable vertebrates lack the GULO gene. Gene structure and phylogenetic analyses showed that vertebrate GULO genes are 64–95% identical at the amino acid level and consist of 11 conserved exons. GULO pseudogenes have multiple indel mutations and premature stop codons in higher primates, guinea pigs, and some bats. No GULO-like sequences were identified in teleost fishes… 
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27 Citations
Background Citations
14
Results Citations
1

27 Citations

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More than 200 evolutionary changes in hard and soft tissue anatomy/morphology, behavior, physiology, and protein constitution are presented in the context of their functional relevance and adaptive value.
iMM1865: A New Reconstruction of Mouse Genome-Scale Metabolic Model
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The Gulo locus might be good candidates for safe Harbor loci for transgenic research, and the utility as the new safe harbor locus in human and mice is examined.
Ascorbate synthesis in fishes: A review
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An up‐to‐date review on ascorbate synthesis in fishes and the possible future directions of study in view of the discovery of the unusual site of asCorbate biosynthesis is provided.
Transport of vitamin C in cancer.
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Understanding vitamin C physiology in tumor survival might be key to decipher the controversies in its relation to cancer, as well as allow the design of new therapeutic approaches in human cancer.
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References

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TLDR
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