Conserved non-coding sequences and transcriptional regulation.

@article{Strhle2008ConservedNS,
  title={Conserved non-coding sequences and transcriptional regulation.},
  author={Uwe Str{\"a}hle and Sepand Rastegar},
  journal={Brain research bulletin},
  year={2008},
  volume={75 2-4},
  pages={
          225-30
        }
}
Genes coding for transcription factors and developmental regulators have a high likelihood to harbour cis-regulatory regions that are structurally conserved among orthologous genes in the vertebrate lineage. These regions can span up to several hundred basepairs with 70 and more percent sequence identity between fish and mammals. Even though this conservation is an efficient tool to discover cis-regulatory regions, we know little about why these specific genes maintain such highly conserved… CONTINUE READING