Conserved modular design of an oxygen sensory/signaling network with species-specific output.

@article{Crosson2005ConservedMD,
  title={Conserved modular design of an oxygen sensory/signaling network with species-specific output.},
  author={Sean Crosson and Patrick T McGrath and Craig Stephens and Harley H. McAdams and Lucy Shapiro},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 22},
  pages={8018-23}
}
Principles of modular design are evident in signaling networks that detect and integrate a given signal and, depending on the organism in which the network module is present, transduce this signal to affect different metabolic or developmental pathways. Here we report a global transcriptional analysis of an oxygen sensory/signaling network in Caulobacter crescentus consisting of the sensor histidine kinase FixL, its cognate response regulator FixJ, the transcriptional regulator FixK, and the… CONTINUE READING

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