Conserved microRNAs in Chinese hamster ovary cell lines.

  title={Conserved microRNAs in Chinese hamster ovary cell lines.},
  author={Kathryn C Johnson and Nitya M. Jacob and Peter Morin Nissom and Matthias J. Hackl and Lim Hseuh Lee and Miranda Gek Sim Yap and Wei-Shou Hu},
  journal={Biotechnology and bioengineering},
  volume={108 2},
MicroRNAs (miRNAs), a class of short (20-24 nt) non-coding RNAs that direct post-transcriptional repression of messenger RNAs, increasingly have been shown to play a key role in regulating cellular physiology. We investigated the prevalence of miRNAs in Chinese hamster ovary (CHO) cells by high-throughput sequencing. Six cDNA libraries of small RNAs from four CHO cell lines were constructed and sequenced by Illumina sequencing. Three hundred fifty distinct miRNA and miRNA* sequences were… CONTINUE READING


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