Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia.

@article{Kalantari2004ConservedMP,
  title={Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia.},
  author={Mina Rezaei Kalantari and Itzel E. Calleja-Macias and Devansu Tewari and Bj\orn M Hagmar and Kathrine Lie and Hugo Alberto Barrera-Salda{\~n}a and Dorothy JoAnn Wiley and H. F. Bernard},
  journal={Journal of virology},
  year={2004},
  volume={78 23},
  pages={12762-72}
}
DNA methylation contributes to the chromatin conformation that represses transcription of human papillomavirus type16 (HPV-16), which is prevalent in the etiology of cervical carcinoma. In an effort to clarify the role of this phenomenon in the regulation and carcinogenicity of HPV-16, 115 clinical samples were studied to establish the methylation patterns of the 19 CpG dinucleotides within the long control region and part of the L1 gene by bisulfite modification, PCR amplification, DNA cloning… CONTINUE READING