Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia.


DNA methylation contributes to the chromatin conformation that represses transcription of human papillomavirus type16 (HPV-16), which is prevalent in the etiology of cervical carcinoma. In an effort to clarify the role of this phenomenon in the regulation and carcinogenicity of HPV-16, 115 clinical samples were studied to establish the methylation patterns… (More)


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