Conserved mRNA-binding proteomes in eukaryotic organisms

  title={Conserved mRNA-binding proteomes in eukaryotic organisms},
  author={Ana M. Matia-Gonz{\'a}lez and Emma E Laing and Andr{\'e} P Gerber},
  booktitle={Nature Structural &Molecular Biology},
RNA-binding proteins (RBPs) are essential for post-transcriptional regulation of gene expression. Recent high-throughput screens have dramatically increased the number of experimentally identified RBPs; however, comprehensive identification of RBPs within living organisms is elusive. Here we describe the repertoire of 765 and 594 proteins that reproducibly interact with polyadenylated mRNAs in Saccharomyces cerevisiae and Caenorhabditis elegans, respectively. Furthermore, we report the… CONTINUE READING
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