Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+.

  title={Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+.},
  author={Lisa L Freeman-Cook and Eliana B. G{\'o}mez and Erik J Spedale and John Marlett and Susan L. Forsburg and Lorraine Pillus and Patricia M Laurenson},
  volume={169 3},
In Schizosaccharomyces pombe, three genes, sir2(+), hst2(+), and hst4(+), encode members of the Sir2 family of conserved NAD(+)-dependent protein deacetylases. The S. pombe sir2(+) gene encodes a nuclear protein that is not essential for viability or for resistance to treatment with UV or a microtubule-destabilizing agent. However, sir2(+) is essential for full transcriptional silencing of centromeres, telomeres, and the cryptic mating-type loci. Chromatin immunoprecipitation results suggest… CONTINUE READING


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