Conserved expression without conserved regulatory sequence: the more things change, the more they stay the same.

@article{Weirauch2010ConservedEW,
  title={Conserved expression without conserved regulatory sequence: the more things change, the more they stay the same.},
  author={Matthew T. Weirauch and Timothy R. Hughes},
  journal={Trends in genetics : TIG},
  year={2010},
  volume={26 2},
  pages={
          66-74
        }
}
Regulatory regions with similar transcriptional output often have little overt sequence similarity, both within and between genomes. Although cis- and trans-regulatory changes can contribute to sequence divergence without dramatically altering gene expression outputs, heterologous DNA often functions similarly in organisms that share little regulatory sequence similarities (e.g. human DNA in fish), indicating that trans-regulatory mechanisms tend to diverge more slowly and can accommodate a… CONTINUE READING
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