Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish.

@article{Thomas2010ConservedEB,
  title={Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish.},
  author={Philippe Thomas and Rebecca A. Alyea and Yefei Pang and Candace Peyton and Jing Dong and Albert H. J. van den Berg},
  journal={Steroids},
  year={2010},
  volume={75 8-9},
  pages={595-602}
}
Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. However, the importance of GPER as an estrogen receptor has been questioned by Otto and co-workers. Some of the pitfalls in investigating the functions of recombinant steroid membrane receptors that may… CONTINUE READING