Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds

@inproceedings{Ziga2012ConservedCR,
  title={Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds},
  author={Aim{\'e}e Z{\'u}{\~n}iga and Fr{\'e}d{\'e}ric Laurent and Javier L{\'o}pez-R{\'i}os and Christian Klasen and Nicolas Matt and Rolf Zeller},
  booktitle={BMC Developmental Biology},
  year={2012}
}
Mouse limb bud is a prime model to study the regulatory interactions that control vertebrate organogenesis. Major aspects of limb bud development are controlled by feedback loops that define a self-regulatory signalling system. The SHH/GREM1/AER-FGF feedback loop forms the core of this signalling system that operates between the posterior mesenchymal organiser and the ectodermal signalling centre. The BMP antagonist Gremlin1 (GREM1) is a critical node in this system, whose dynamic expression is… CONTINUE READING
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