Conserved boxes C and D are essential nucleolar localization elements of U14 and U8 snoRNAs.

@article{Lange1998ConservedBC,
  title={Conserved boxes C and D are essential nucleolar localization elements of U14 and U8 snoRNAs.},
  author={Thilo Sascha Lange and Anton V. Borovjagin and E. S. Maxwell and Susan A Gerbi},
  journal={The EMBO journal},
  year={1998},
  volume={17 11},
  pages={3176-87}
}
Sequences necessary for nucleolar targeting were identified in Box C/D small nucleolar RNAs (snoRNAs) by fluorescence microscopy. Nucleolar preparations were examined after injecting fluorescein-labelled wild-type and mutated U14 or U8 snoRNA into Xenopus oocyte nuclei. Regions in U14 snoRNA that are complementary to 18S rRNA and necessary for rRNA processing and methylation are not required for nucleolar localization. Truncated U14 molecules containing Boxes C and D with or without the… CONTINUE READING

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