Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor.

@article{Gumperz1997ConservedAV,
  title={Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor.},
  author={Jenny E Gumperz and Linda D. Barber and Nicholas M. Valiante and Lucy Percival and Joseph H. Phillips and Lewis L. Lanier and Peter Parham},
  journal={Journal of immunology},
  year={1997},
  volume={158 11},
  pages={5237-41}
}
Allotypes from four divergent HLA-B families (B8, B15, B16, and B27) were compared for their inhibition of cytolysis by NK cells expressing the NKB1 receptor. Allotypes differing solely at the Bw4/Bw6 region were examined as were a more divergent subset of B15 allotypes. The capacity to interact with NKB1 correlated precisely with possession of a Bw4 sequence motif at residues 77-83, whereas no correlation was made with the peptide-binding specificities of two Bw4 and four Bw6 allotypes of the… CONTINUE READING