Conserved and specific functions of mammalian ssu72

@article{StPierre2005ConservedAS,
  title={Conserved and specific functions of mammalian ssu72},
  author={Benoit St-Pierre and Xudong Liu and Lan-Chau T. Kha and Xudong Zhu and Owen W. Ryan and Zhe Jiang and Eldad Zacksenhaus},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={464 - 477}
}
We describe the cloning and characterization of a human homolog of the yeast transcription/RNA-processing factor Ssu72, following a yeast two-hybrid screen for pRb-binding factors in the prostate gland. Interaction between hSsu72 and pRb was observed in transfected mammalian cells and involved multiple domains in pRb; however, so far, mutual effects of these two factors could not be demonstrated. Like the yeast counterpart, mammalian Ssu72 associates with TFIIB and the yeast cleavage… CONTINUE READING

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