Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.

  title={Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.},
  author={Nils Olof Lindstr{\"o}m and Jill A. McMahon and Jinjin Guo and Tracy C Tran and Qiuyu Guo and Elisabeth A Rutledge and Riana K. Parvez and Gohar Saribekyan and Robert Schuler and Christopher Liao and Albert D Kim and Ahmed Abdelhalim and Seth W Ruffins and Matthew E Thornton and Laurence S. Baskin and Brendan H Grubbs and Carl Kesselman and Andrew P. McMahon},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={29 3},
Human kidney function is underpinned by approximately 1,000,000 nephrons, although the number varies substantially, and low nephron number is linked to disease. Human kidney development initiates around 4 weeks of gestation and ends around 34-37 weeks of gestation. Over this period, a reiterative inductive process establishes the nephron complement. Studies have provided insightful anatomic descriptions of human kidney development, but the limited histologic views are not readily accessible to… CONTINUE READING
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