Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding

@inproceedings{Ozanick2007ConservedAA,
  title={Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding},
  author={Sarah G. Ozanick and Janusz M. Bujnicki and Daniel S. Sem and James T Anderson},
  booktitle={Nucleic acids research},
  year={2007}
}
In Saccharomyces cerevisiae, a two-subunit methyltransferase (Mtase) encoded by the essential genes TRM6 and TRM61 is responsible for the formation of 1-methyladenosine, a modified nucleoside found at position 58 in tRNA that is critical for the stability of tRNA(Met)i The crystal structure of the homotetrameric m1A58 tRNA Mtase from Mycobacterium tuberculosis, TrmI, has been solved and was used as a template to build a model of the yeast m1A58 tRNA Mtase heterotetramer. We altered amino acids… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

( m 1 G 37 ) methyltransferase from Salmonella typhimurium affect tRNA substrate specificity

  • K. Watanabe, O. Nureki, S. Fukai, Y. Endo, H. Hori
  • 2006

Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase

  • I. Zegers, D. Gigot, +5 authors L. Droogmans
  • Nucleic Acids Res,
  • 2006

Crystal structure of Bacillus subtilis TrmB , the tRNA ( m 7 G 46 ) methyltransfer

  • M. J. O. Johansson, A. S. Bystrom
  • Nucleic Acids Res
  • 2005

Sequencestructure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis

  • E. Purta, F. van Vliet, +5 authors J. M. Bujnicki
  • Proteins
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…