Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein.

@article{Guy2004ConservedAA,
  title={Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein.},
  author={Jackson Guy and Chad S. Hunter and Aaron D. Showalter and Timothy L Smith and Kanokwan Charoonpatrapong and Kyle W Sloop and Joseph P. Bidwell and Simon Rhodes},
  journal={Gene},
  year={2004},
  volume={336 2},
  pages={263-73}
}
Prophet of Pit-1 (PROP1) is a homeodomain transcription factor essential for development of the mammalian anterior pituitary gland. Studies of human patients and animal models with mutations in their Prop1 genes have established that PROP1 is required for the correct development or sustained function of the hormone-secreting cells that regulate physiological pathways controlling growth, reproduction, metabolism, and the stress response. By comparative analysis of mammalian Prop1 genes and their… CONTINUE READING
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