Conserved activation pathways in G-protein-coupled receptors.

  title={Conserved activation pathways in G-protein-coupled receptors.},
  author={Xavier Deup{\'i} and Joerg Standfuss and Gebhard F. X. Schertler},
  journal={Biochemical Society transactions},
  volume={40 2},
GPCRs (G-protein-coupled receptors) are seven-transmembrane helix proteins that transduce exogenous and endogenous signals to modulate the activity of downstream effectors inside the cell. Despite the relevance of these proteins in human physiology and pharmaceutical research, we only recently started to understand the structural basis of their activation mechanism. In the period 2008-2011, nine active-like structures of GPCRs were solved. Among them, we have determined the structure of light… CONTINUE READING
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