Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope.

@article{Kedzierska2004ConservedTC,
  title={Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope.},
  author={Katherine Kedzierska and Stephen John Turner and Peter C. Doherty},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 14},
  pages={4942-7}
}
The CD8+ T cell response to the immunodominant DbNP366 epitope has been analyzed sequentially to determine the prevalence and persistence of different T cell antigen receptor (TCR)Vbeta8.3 clonotypes after primary and secondary influenza virus challenge. Based on the length and amino acid sequences of the complementarity-determining region 3 of TCRbeta (CDR3beta) loop and associated Jbeta usage, the same dominant TCRbeta signatures were found in the blood, the spleen, and the site of virus… CONTINUE READING

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