Conserved Ser residues, the shutter region, and speciation in serpin evolution.

  title={Conserved Ser residues, the shutter region, and speciation in serpin evolution.},
  author={Maxwell M. Krem and Enrico Di Cera},
  journal={The Journal of biological chemistry},
  volume={278 39},
The suicide inhibitory mechanism of serine protease inhibitors of the serpin superfamily depends heavily on their structural flexibility, which is controlled in large part by the breach and shutter regions of the central Abeta-sheet. We examined codon usage by the highly conserved residues, Ser-53 and Ser-56, of the shutter region and found a TCN-AGY usage dichotomy for Ser-56 that remarkably is linked to the protostome-deuterostome split. Our results suggest that serpin evolution was driven by… CONTINUE READING

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PHYLIP (Phylogeny Inference Package), version 3.5c, Department of Genetics

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