Conserved Molecular Interactions in Centriole-to-Centrosome Conversion

@inproceedings{Fu2016ConservedMI,
  title={Conserved Molecular Interactions in Centriole-to-Centrosome Conversion},
  author={Jingyan Fu and Zolt{\'a}n Lipinszki and H{\'e}l{\`e}ne Rangone and Mingwei Min and Charlotte Mykura and Jennifer Chao-Chu and Sandra Schneider and Nikola S. Dzhindzhev and Marco Gottardo and Maria Giovanna Riparbelli and Giuliano Callaini and David M Glover},
  booktitle={Nature Cell Biology},
  year={2016}
}
Centrioles are required to assemble centrosomes for cell division and cilia for motility and signalling. New centrioles assemble perpendicularly to pre-existing ones in G1–S and elongate throughout S and G2. Fully elongated daughter centrioles are converted into centrosomes during mitosis to be able to duplicate and organize pericentriolar material in the next cell cycle. Here we show that centriole-to-centrosome conversion requires sequential loading of Cep135, Ana1 (Cep295) and Asterless… CONTINUE READING

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