Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis.

@article{Alamo2016ConservedII,
  title={Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis.},
  author={Lorenzo Alamo and Dan Qi and Willy Wriggers and Ant{\'o}nio Pinto and Jingui Zhu and Aivett Bilbao and Richard E. Gillilan and Songnian Hu and Ra{\'u}l Padr{\'o}n},
  journal={Journal of molecular biology},
  year={2016},
  volume={428 6},
  pages={1142-1164}
}
Tarantula striated muscle is an outstanding system for understanding the molecular organization of myosin filaments. Three-dimensional reconstruction based on cryo-electron microscopy images and single-particle image processing revealed that, in a relaxed state, myosin molecules undergo intramolecular head-head interactions, explaining why head activity switches off. The filament model obtained by rigidly docking a chicken smooth muscle myosin structure to the reconstruction was improved by… CONTINUE READING
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Conserved intramolecular interactions maintain myosin interacting - heads motifs explaining tarantula muscle super - relaxed state structural basis

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Improved imaging, 3D reconstruction and homology modelling of tarantula thick filaments

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