Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses.

@article{Liu2009ConservedHE,
  title={Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses.},
  author={Yi Liu and John McNevin and Morgane Rolland and Hong Lei Zhao and Wenjie Deng and Janine Maenza and Claire E. Stevens and Ann C Collier and M Juliana McElrath and James I. Mullins},
  journal={The Journal of infectious diseases},
  year={2009},
  volume={200 12},
  pages={1825-33}
}
BACKGROUND The epitope specificities and antiviral activities of class I HLA-restricted CD8(+) T cells, especially those induced during human immunodeficiency virus type 1 (HIV-1) primary infection, are important considerations in designing HIV-1 vaccines. Conserved epitopes may be more commonly and persistently recognized than variable epitopes, as they may be more likely to be present in infecting viruses. However, some studies have shown preferential or similar targeting of variable versus… CONTINUE READING
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Escape from the dominant HLA-B27 restricted CTL response in Gag is associated with a dramatic reduction in HIV-1 replication

  • A Schneidewind, MA Brockman, R Yang
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