Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution

Abstract

Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data to identify more than 550 distinct lincRNAs in zebrafish. Although these shared many characteristics with mammalian lincRNAs, only 29… (More)
DOI: 10.1016/j.cell.2012.10.002

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Cite this paper

@article{Ulitsky2011ConservedFO, title={Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution}, author={Igor Ulitsky and Alena Shkumatava and Calvin H. Jan and Hazel L. Sive and David P Bartel}, journal={Cell}, year={2011}, volume={147}, pages={1537-1550} }