Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons.


mRNA localization provides polarized cells with a locally renewable source of proteins. In neurons, mRNA translation can occur at millimeters to centimeters from the cell body, giving the dendritic and axonal processes a means to autonomously respond to their environment. Despite that hundreds of mRNAs have been detected in neuronal processes, there are no… (More)
DOI: 10.1074/jbc.M109.061333