Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus.

@article{Kim2011ConservedDR,
  title={Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus.},
  author={Yoon Jung Kim and Katharine R Cecchini and Tae Hoon Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 18},
  pages={
          7391-6
        }
}
Establishment and segregation of distinct chromatin domains are essential for proper genome function. The insulator protein CCCTC-binding factor (CTCF) is involved in creating boundaries that segregate chromatin and functional domains and in organizing higher-order chromatin structures by promoting chromosomal loops across the vertebrate genome. Here, we investigate the insulation properties of CTCF at the human and mouse homeobox gene A (HOXA) loci. Although cohesin loading at the CTCF binding… CONTINUE READING
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