Conservative system for dosage-dependent modulation of translational fidelity in eukaryotes.

@article{Chernoff1992ConservativeSF,
  title={Conservative system for dosage-dependent modulation of translational fidelity in eukaryotes.},
  author={Yury O Chernoff and M V Ptyushkina and Maria G. Samsonova and G I Sizonencko and Yu. I. Pavlov and Michael D. Ter-Avanesyan and Sergey G. Inge-Vechtomov},
  journal={Biochimie},
  year={1992},
  volume={74 5},
  pages={455-61}
}
Variations in dosage of some genes can alter the level of translational fidelity. The Saccharomyces cerevisiae genes that act as dosage-dependent suppressors and/or modulators of suppression, are the following: some tRNA genes (for example, tRNA(Gln)) inducing readthrough by mispairing; genes coding for either translational elongation factor or other proteins taking part in translation; and some genes of unknown function. We suggest that the SUP35 protein is a factor which may play a major role… CONTINUE READING