Conservative inheritance of newly synthesized DNA in double-strand break-induced gene conversion.

@article{Ira2006ConservativeIO,
  title={Conservative inheritance of newly synthesized DNA in double-strand break-induced gene conversion.},
  author={Grzegorz Ira and Dominik Satory and James E Haber},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 24},
  pages={
          9424-9
        }
}
To distinguish among possible mechanisms of repair of a double-strand break (DSB) by gene conversion in budding yeast, Saccharomyces cerevisiae, we employed isotope density transfer to analyze budding yeast mating type (MAT) gene switching in G2/M-arrested cells. Both of the newly synthesized DNA strands created during gene conversion are found at the repaired locus, leaving the donor unchanged. These results support suggestions that mitotic DSBs are primarily repaired by a synthesis-dependent… CONTINUE READING

Similar Papers

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

Error-Prone Repair of DNA Double-Strand Breaks.

  • Journal of cellular physiology
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Srs 2 and Sgs 1 - Top 3 suppress crossovers during double - strand break repair in yeast

A. Pellicioli, A. Balijja, +8 authors M. Foiani
  • Cell
  • 2004