Conservative, Non-conservative and Average Pairwise Statistical Significance of Local Sequence Alignment

@article{Agrawal2008ConservativeNA,
  title={Conservative, Non-conservative and Average Pairwise Statistical Significance of Local Sequence Alignment},
  author={Ankit Agrawal and Xiaoqiu Huang},
  journal={2008 IEEE International Conference on Bioinformatics and Biomedicine},
  year={2008},
  pages={433-436}
}
Estimation of statistical significance of a pairwise alignment is an important problem in sequence comparison. Recently, it was shown that pairwise statistical significance does better in practice than database statistical significance in terms of retrieval accuracy of homologs. In this paper, we introduce the concept of conservative, non-conservative, and average pairwise statistical significance which can be easily derived from original pairwise statistical significance estimates and use more… CONTINUE READING

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