Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease.

@article{Marshall2007ConservationOV,
  title={Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease.},
  author={Vickie A Marshall and Thomas A. Parks and Rachel Bagni and Cheng Dian Wang and Mark Atienza Samols and Jianhong Hu and Kathleen M Wyvil and Karen A. Aleman and Richard F Little and Robert Yarchoan and Rolf Renne and Denise Whitby},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 5},
  pages={
          645-59
        }
}
BACKGROUND MicroRNAs are small noncoding RNAs that posttranscriptionally regulate gene expression. Kaposi sarcoma (KS)-associated herpesvirus (KSHV) encodes 12 distinct microRNA genes, all of which are located within the latency-associated region that is highly expressed in all KSHV-associated malignancies. METHODS We amplified, cloned, and sequenced a 2.8-kbp-long region containing a cluster of 10 microRNAs plus a 646-bp fragment of K12/T0.7 containing the remaining 2 microRNAs from 5… CONTINUE READING

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