Conservation of transcription factor binding specificities across 600 million years of bilateria evolution

@inproceedings{Nitta2015ConservationOT,
  title={Conservation of transcription factor binding specificities across 600 million years of bilateria evolution},
  author={Kazuhiro R. Nitta and Arttu Jolma and Yimeng Yin and Ekaterina Morgunova and Teemu Kivioja and Junaid Akhtar and Korneel Hens and Jarkko Toivonen and Bart Deplancke and Eileen E. M. Furlong and Jussi Taipale},
  booktitle={eLife},
  year={2015}
}
Divergent morphology of species has largely been ascribed to genetic differences in the tissue-specific expression of proteins, which could be achieved by divergence in cis-regulatory elements or by altering the binding specificity of transcription factors (TFs). The relative importance of the latter has been difficult to assess, as previous systematic analyses of TF binding specificity have been performed using different methods in different species. To address this, we determined the binding… CONTINUE READING
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